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   Index



 

PAPAVERACEAE

(Poppy family)

 

200 species in 26 genera are chiefly found in north temperate regions.

A number of species are grown as annual or perennial ornamentals in gardens and parks, including Papaver glaucum (tulip poppy), Papaver rhoeas (corn poppy), Papaver somniferum (opium poppy), Papaver nudicaule (Iceland poppy), Papaver orientale (oriental poppy), and Papaver rupifragum (Spanish poppy). The popular annual Shirley poppies are derived from Papaver rhoeas (Hunt 1968/70).

[Summary yet to be added]


Argemone mexicana L.
Thistleroot, Mexican Poppy, Prickly Poppy

The prickles on the leaves and fruiting capsules can cause mechanical injury to humans and grazing animals (Oakes and Butcher 1962). The acrid yellow sap has slightly corrosive properties (Dalziel 1937, Quisumbing 1951) and the plant can cause dermatitis in some individuals (Behl et al. 1966). Patch tests carried out using the leaves of this species crushed in a small quantity of normal saline elicited positive reactions in 2 of 20 contact dermatitis patients tested in New Delhi, India (Singh et al. 1978).

Stuart (1911) noted that in Chinese traditional medicine, the oil expressed from the seeds of this plant (which is known as Lao Shu Le) is said to allay the irritation of herpes and many other eruptions of the skin. The seed is a common adulterant of mustard seed (Brassica) either by chance or for profit. Ingestion of argemone seed oil has caused epidemic dropsy in humans in Africa and India with hyperpigmentation of the skin and "sarcoidal" angiomatous swellings and glaucoma (Watt & Breyer-Brandwijk 1962).

Berberine, one of the alkaloids derived from the plant, produces intense pain when infiltrated into the conjunctiva for the treatment of trachoma or into the skin for the treatment of leishmaniasis (Watt & Breyer-Brandwijk 1962). Berberine, when injected as a local anaesthetic, occasionally produces hyperpigmentation at the site of injection (Seery and Bieter 1940). Reactions to berberine are also noted under Berberis.



Argemone platyceras Link & Otto
Rough Prickly Poppy, Thistle Poppy

This species can produce mechanical injury (Muenscher 1951).



Argemone subalpina McDonald

McDonald (1991) described this spiny species from subalpine regions of Sierra Peña Nevada, Mexico as being closely related to Argemone platyceras Link & Otto (see above).



Bocconia sp.

Injection of an extract of the plant produces local anaesthesia but there is also an irritant effect (Martinez 1969).



Chelidonium majus L.
Tetterwort, Greater Celandine, Rock Poppy

Dioscorides (1st Century A.D.) referred to a bitter and biting nature of the plant. According to Wren (1975) the fresh juice makes an excellent application for corns and warts, and an infusion of the herb has been used orally in the treatment of jaundice, scrofulous diseases and eczema. In Chinese traditional medicine, the dried whole plant (known as Bai Qu Cai) is applied externally in the form of an ointment or paste to treat insect bites and infections (Huang 1993).

The fresh juice - which is bright orange in colour - when applied to the skin, is acrid, irritant and vesicant, and even escharotic (Loudon 1855, Van Hasselt 1862, Oesterlen 1856, US Dispensatory 1884, Cheney cited by White 1887, Piffard 1881). According to North (1967) the plant, which is commonly found near old walls and ruins in most parts of England and Wales, can produce dermatitis. Hardin and Arena (1974) also refer to dermatitis from the plant in the US and Canada. The sap of the plant is also irritating to the eye (Hilbert 1916) but was at one time used to treat opacities of the cornea to improve eyesight.

The plant contains a variety of alkaloids including chelidonine, chelerythrine, and berberine, and also chelidonic acid. Chelidonic acid is an acrid irritant which has been used to treat warts. Repeated subcutaneous injections for the treatment of an epithelioma of the eyelid produced much reaction and pain after each injection and the lids sloughed and scarred up to the orbital margin (Duke-Elder & MacFaul 1972b).

The genus is monotypic. The plant is botanically unrelated to the lesser celandine, Ranunculus ficaria L., fam. Ranunculaceae.



Glaucium flavum Crantz
Yellow Horned Poppy

This species has irritant properties (Pammel 1911).



Meconopsis horridula Hook. f. & Thomson
Tibetan Poppy, Spiny Meconopsis, Prickly Blue Poppy, Blue Thorned Poppy

This plant, which is occasionally grown as an ornamental for its showy blue flowers (Hunt 1968/70), has spiny foliage and stems.



Papaver dubium L.
Long-Headed Poppy

Gardner & Bennetts (1956) include this species in a list of plants known or suspected of causing dermatitis.



Papaver rhoeas L.
Field Poppy, Corn Poppy, Common Poppy, Red Poppy

The plant has irritant properties (Pammel 1911).



Papaver somniferum L.
Opium Poppy

Opium, the dried latex of the unripe capsule, yields about 20 alkaloids including morphine. Contact dermatitis occurred in a worker in a morphine factory who had washed some cloths through which morphia had been filtered (Lewin 1908), and in nurses who made morphine tablets (Dore and Thomas 1944, Jordon and Osborne 1939). Crude morphine produced dermatitis in factory-workers and patch tests with morphine hydrochloride produced negative results (Dore and Thomas 1944, Green 1944). Morphine itself has produced strong sensitivity; a nurse showed a positive patch test reaction to morphine solutions diluted to 1 in 1,000,000 and exposure to the air in a ward produced clinical symptoms (Jordon and Osborne 1939). Ethylmorphine can cause dermatitis of the eyelids (Duke-Elder 1965, Cummer 1931). Opium applied to the skin caused dermatitis of the genitals (Heller 1931). Contact dermatitis from morphine or its unidentified impurities is most likely to occur at the factory level where mechanical handling is avoided and the compounds are worked largely by hand. Panniculitis can occur in morphine addicts (Lopez et al. 1961).

The plant was cultivated as a source of cooking oil by Egyptians as early as 1500 B.C. The seed which is free of narcotic properties provides oil and the treated seed is used as a condiment for poppyseed cake and bread.



Roemeria hybrida DC.
(syn. Chelidonium hybridum Medikus, Roemeria violacea Medikus)
Purple Horned Poppy

Roemeria violacea has irritant properties (Pammel 1911).



Sanguinaria canadensis L.
Blood Root, Red Puccoon, Tetterwort

The genus Sanguinaria L. comprises this single species, which is found growing naturally in eastern North America (Mabberley 1987). The name sanguinaria refers to the fact that the plant, when wounded, throws out a copious blood-like sap - a property well known to the American Indians, who used the red sap as a dye (Felter & Lloyd 1898).

The rhizome of this plant provides Sanguinaria, which was formerly included in both British and US Pharmacopeias. According to Felter & Lloyd (1898), the dried and powdered root, when inhaled, is exceedingly irritant to the nasal passages and provokes sneezing - this property evidently contributing in some way to its reported use as a snuff for the treatment of nasal polyps. Felter & Lloyd (1898) also state that: "Sanguinaria is of value in syphilitic skin eruptions, and, as an ointment, has been employed, locally, in tinea. The powder, made into a cataplasm with slippery-elm, has been used in domestic practice as a local dressing for frozen feet. An infusion, made in vinegar, has been found valuable in several cutaneous diseases, as eczema, ringworm, and warts. At one time the root was extensively employed in the treatment of carcinomata, and was also applied to exuberant excrescences for its escharotic action, and to ill-conditioned ulcers, to create a healthy energy in the sores." Both Wren (1975) and Stuart (1979) allude to these early uses.

A female laboratory worker developed a vesicular eruption on the fingers, face, neck and chest one day after handling Sanguinaris powder. It is possible that she had been exposed to poison ivy (Toxicodendron) three days previously (Fox 1921).


References

  • Behl, P.N., Captain, R.M., Bedi, B.M.S. and Gupta, S. (1966) Skin-irritant and Sensitizing Plants found in India, New Delhi. P.N. Behl, Irwin Hospital.
  • Cummer, C.L. (1931) Dermatitis of the eyelids caused by dionin. Archs Derm. Syph. 23: 68.
  • Dalziel, J.M. (1937) The Useful Plants of West Tropical Africa. London. Crown Agents.
  • Dioscorides, The Greek Herbal of: Englished by John Goodyer: A.D. 1655. Edited and first printed A.D. 1933 by R.T. Gunther 1959. New York. Hafner Publishing Co. 2: 206.
  • Dore, S.E. and Thomas, E.W.P. (1944) Contact dermatitis in a morphine factory. Brit. J. Derm. Syph. 56: 177.
  • Duke-Elder, S. (1965) System of Ophthalmology. Vol. VIII. Diseases of the Outer Eye. Part 1. Allergic Kerato-Conjunctivitis. pp. 451. London. Henry Kimpton.
  • Duke-Elder S, MacFaul PA (1972b) System of Ophthalmology, Vol. XIV. Injuries Part 2. Non-Mechanical Injuries. London: Henry Kimpton
  • Felter HW and Lloyd JU (1898) King's American Dispensatory. 18th edn; 3rd revn. Vol. I & II. Cincinnatti: Ohio Valley
  • Fox, H. (1921) Dermatitis venenata from oriental cashew nut. Archs Derm. Syph. 3: 202.
  • Gardner CA and Bennetts HW (1956) The Toxic Plants of Western Australia. Perth: West Australian Newspapers
  • Green, G.C. (1944) The occurrence of "morphia rash" in the manufacture of morphine salts from opium. Brit. J. Derm. Syph. 56: 182.
  • Hardin JW and Arena JM (1974) Human Poisoning from Native and Cultivated Plants, 2nd edn. Durham, North Carolina: Duke University Press.
  • Heller, N.B. (1931) Acute dermatitis due to opium preparations. Archs Derm. Syph. 24: 417.
  • Hilbert, R. (1916) Iritis durch Einwirkung des Milchsaftes von Chelidonium majus L. Zbl. Brakt. Augenh 40: 142.
  • Huang KC (1993) The Pharmacology of Chinese Herbs. Boca Raton, Florida: CRC Press
  • Hunt P (Ed.) (1968/70) The Marshall Cavendish Encyclopedia of Gardening. London: Marshall Cavendish [WorldCat]
  • Jordon JW, Osborne ED (1939) Contact dermatitis from opium derivatives with special reference to occupational aspects. Journal of the American Medical Association 113(22): 1955-1957
  • Lewin L (1908) Die gewerbliche Vergiftung der Haut durch Morphin und Opium. Ein Obergutachten. Medizinische Klinik 4(43): 1633-1636
  • Lopez, P.B., Baquero, G.F. and De la Solana, J.G. (1961) Subcutaneous fatty necrosis (panniculitis in a morphine addict). Bol. Soc. Cuba, Derm. Sif. 18: 35.
  • Loudon JC, Loudon JW, Don G, Wooster D (1855) Loudon's Encyclopædia of Plants : comprising the specific character, description, culture, history, application in the arts, and every other desirable particular respecting all the plants indigenous to, cultivated in, or introduced to Britain. London: Longman, Brown, Green, and Longmans [WorldCat]
  • Martinez, M. (1969) The Medicinal Plants of Mexico. 5th ed. Mexico City. Andres Botas.
  • Muenscher, W.C. (1951) Poisonous Plants of the United States. 2nd edn. New York, The Macmillan Co.
  • North, P.M. (1967) Poisonous Plants and Fungi in Colour. London. Blandford Press Ltd.
  • Oakes AJ and Butcher JO (1962) Poisonous and Injurious Plants of the U.S. Virgin Islands. Miscellaneous Publication No. 882. Washington, DC: Agricultural Research Service, United States Department of Agriculture
  • Oesterlen (1956) Handbuch der Heilmittellehre. Tubingen cited by White (1887)
  • Pammel LH (1911) A Manual of Poisonous Plants. Chiefly of North America, with Brief Notes on Economic and Medicinal Plants, and Numerous Illustrations. Cedar Rapids, IA: Torch Press [WorldCat] [url] [url-2]
  • Piffard, H.G. (1881) A Treatise on the Materia Medica and Therapeutics of the Skin. New York. Wm Wood and Co.
  • Quisumbing, E. (1951) Medicinal Plants of the Philippines. Tech. Bull. 16. Manila, Philippine Islands. Manila Bureau of Printing. 1234 pp.
  • Seery, T.M. and Bieter, R.N. (1940) A contribution to the pharmacology of berberine. J. Pharmacol. 69: 64.
  • Singh R, Siddiqui MA, Baruah MC (1978) Plant dermatitis in Delhi. Indian Journal of Medical Research 68(Oct): 650-655
  • Stuart GA (1911) Chinese Materia Medica. Vegetable Kingdom. Shanghai: American Presbyterian Mission Press
  • Stuart M (1979) Reference section. In: Stuart M (Ed.) The Encyclopedia of Herbs and Herbalism. pp. 141-283. London: Orbis Publishing
  • US Dispensatory, The National (1884) Philadelphia. Stille and Maisch. Cited by White (1887).
  • Van Hasselt AWM, Henkel JB (1862) Handbuch der Giftlehre für Chemiker, Ärzte, Apotheker und Gerichtspersonen, Vol 1, Allgemeine Giftlehre und die Gifte des Pflanzenreichs. Braunschweig: Friedrich Vieweg und Sohn [WorldCat] [url] [url-2]
  • Watt JM, Breyer-Brandwijk MG (1962) The Medicinal and Poisonous Plants of Southern and Eastern Africa. Being an account of their medicinal and other uses, chemical composition, pharmacological effects and toxicology in man and animal, 2nd edn. Edinburgh: E & S Livingstone [WorldCat] [url]
  • White, J.C. (1887) Dermatitis Venenata: An Account of the Action of External Irritants upon the Skin. Boston. Cupples and Hurd.
  • Wren RC (1975) Potter's New Cyclopaedia of Botanical Drugs and Preparations. (Re-edited and enlarged by Wren RW). Bradford, Devon: Health Science Press [WorldCat] [url] [url-2]



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